MovDisordV3, Main, Exploration, bibRecord, 003383

In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in progressive supranuclear palsy

Identifieur interne : 003383 ( Main/Exploration ); précédent : 003382; suivant : 003384

In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in progressive supranuclear palsy

Auteurs : Alexander Gerhard [Royaume-Uni] ; Iris Trender-Gerhard [Royaume-Uni] ; Federico Turkheimer [Royaume-Uni] ; Niall P. Quinn [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; David J. Brooks [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-01.

RBID : ISTEX:E14D0B5AA49F9AF524160B710910B34A5E119563

Descripteurs français

Pascal (Inist)
- Microglie, Positon, Système nerveux pathologie, Tomographie émission positon, Tomoscintigraphie.

English descriptors

KwdEn :
- Aged, Basal Ganglia (physiopathology), Basal Ganglia (radionuclide imaging), Brain Stem (physiopathology), Brain Stem (radionuclide imaging), Carbon Radioisotopes (diagnostic use), Cell Death (physiology), Emission tomography, Female, Frontal Lobe (physiopathology), Frontal Lobe (radionuclide imaging), Humans, Image Processing, Computer-Assisted, Isoquinolines (diagnostic use), Magnetic Resonance Imaging, Male, Microglia, Microglia (physiology), Microglia (radionuclide imaging), Middle Aged, Nervous system diseases, Neurodegenerative Diseases (physiopathology), Neurodegenerative Diseases (radionuclide imaging), Neurons (physiology), Positron, Positron emission tomography, Receptors, GABA-A (physiology), Reference Values, Stereoisomerism, Supranuclear Palsy, Progressive (physiopathology), Supranuclear Palsy, Progressive (radionuclide imaging), [11C](R)‐PK11195 PET, activated microglia, progressive supranuclear palsy.
MESH :
- chemical , diagnostic use : Carbon Radioisotopes, Isoquinolines.
- physiology : Cell Death, Microglia, Neurons, Receptors, GABA-A.
- physiopathology : Basal Ganglia, Brain Stem, Frontal Lobe, Neurodegenerative Diseases, Supranuclear Palsy, Progressive.
- radionuclide imaging : Basal Ganglia, Brain Stem, Frontal Lobe, Microglia, Neurodegenerative Diseases, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Stereoisomerism.

Abstract

Progressive supranuclear palsy (PSP) is a neurodegenerative disease presenting with voluntary gaze difficulties, early falls, and Parkinsonism. Neuronal loss, associated with intracellular neurofibrillary tangles and activated microglia, is found targeting the basal ganglia, brainstem nuclei, and frontal cortex. [11C](R)‐PK11195 PET is a marker of peripheral benzodiazepine binding sites (PBBS) expressed by activated microglia. We have used [11C](R)‐PK11195 PET to demonstrate in vivo the degree and distribution of the glial response to the degenerative process in four patients with PSP. Compared to normal age‐matched controls, the PSP patient group showed significantly increased mean [11C](R)‐PK11195 binding in the basal ganglia, midbrain, the frontal lobe, and the cerebellum. Two of the patients were rescanned after 6 to 10 months and during that time the level of microglial activation remained stable. [11C](R)‐PK11195 PET reveals a pattern of increased microglial activation in PSP patients involving cortical and subcortical regions that corresponds well with the known distribution of neuropathological changes. [11C](R)‐PK11195 PET, therefore, may help in characterizing in vivo the underlying disease activity in PSP. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/E14D0B5AA49F9AF524160B710910B34A5E119563/fulltext/pdf

DOI: 10.1002/mds.20668

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in progressive supranuclear palsy</title>
<author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name>
</author>
<author><name sortKey="Trender Erhard, Iris" sort="Trender Erhard, Iris" uniqKey="Trender Erhard I" first="Iris" last="Trender-Gerhard">Iris Trender-Gerhard</name>
</author>
<author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
</author>
<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:E14D0B5AA49F9AF524160B710910B34A5E119563</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1002/mds.20668</idno>
<idno type="url">https://api.istex.fr/document/E14D0B5AA49F9AF524160B710910B34A5E119563/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002B66</idno>
<idno type="wicri:Area/Istex/Curation">002B66</idno>
<idno type="wicri:Area/Istex/Checkpoint">001E42</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Gerhard A:in:vivo:imaging</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:16108021</idno>
<idno type="wicri:Area/PubMed/Corpus">002F14</idno>
<idno type="wicri:Area/PubMed/Curation">002F14</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002C74</idno>
<idno type="wicri:Area/Ncbi/Merge">001398</idno>
<idno type="wicri:Area/Ncbi/Curation">001398</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001398</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Gerhard A:in:vivo:imaging</idno>
<idno type="wicri:Area/Main/Merge">004696</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:06-0135502</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001C80</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001041</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001A55</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Gerhard A:in:vivo:imaging</idno>
<idno type="wicri:Area/Main/Merge">004B50</idno>
<idno type="wicri:Area/Main/Curation">003383</idno>
<idno type="wicri:Area/Main/Exploration">003383</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in progressive supranuclear palsy</title>
<author><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trender Erhard, Iris" sort="Trender Erhard, Iris" uniqKey="Trender Erhard I" first="Iris" last="Trender-Gerhard">Iris Trender-Gerhard</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Hospital for Neurology and Neurosurgery and Sobell Department of Motor Neuroscience and Movement Disorders, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Hospital for Neurology and Neurosurgery and Sobell Department of Motor Neuroscience and Movement Disorders, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Hospital for Neurology and Neurosurgery and Sobell Department of Motor Neuroscience and Movement Disorders, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2006-01">2006-01</date>
<biblScope unit="vol">21</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="89">89</biblScope>
<biblScope unit="page" to="93">93</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">E14D0B5AA49F9AF524160B710910B34A5E119563</idno>
<idno type="DOI">10.1002/mds.20668</idno>
<idno type="ArticleID">MDS20668</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Basal Ganglia (physiopathology)</term>
<term>Basal Ganglia (radionuclide imaging)</term>
<term>Brain Stem (physiopathology)</term>
<term>Brain Stem (radionuclide imaging)</term>
<term>Carbon Radioisotopes (diagnostic use)</term>
<term>Cell Death (physiology)</term>
<term>Emission tomography</term>
<term>Female</term>
<term>Frontal Lobe (physiopathology)</term>
<term>Frontal Lobe (radionuclide imaging)</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Isoquinolines (diagnostic use)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Microglia</term>
<term>Microglia (physiology)</term>
<term>Microglia (radionuclide imaging)</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neurodegenerative Diseases (physiopathology)</term>
<term>Neurodegenerative Diseases (radionuclide imaging)</term>
<term>Neurons (physiology)</term>
<term>Positron</term>
<term>Positron emission tomography</term>
<term>Receptors, GABA-A (physiology)</term>
<term>Reference Values</term>
<term>Stereoisomerism</term>
<term>Supranuclear Palsy, Progressive (physiopathology)</term>
<term>Supranuclear Palsy, Progressive (radionuclide imaging)</term>
<term>[11C](R)‐PK11195 PET</term>
<term>activated microglia</term>
<term>progressive supranuclear palsy</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Carbon Radioisotopes</term>
<term>Isoquinolines</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Death</term>
<term>Microglia</term>
<term>Neurons</term>
<term>Receptors, GABA-A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Brain Stem</term>
<term>Frontal Lobe</term>
<term>Neurodegenerative Diseases</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Basal Ganglia</term>
<term>Brain Stem</term>
<term>Frontal Lobe</term>
<term>Microglia</term>
<term>Neurodegenerative Diseases</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reference Values</term>
<term>Stereoisomerism</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Microglie</term>
<term>Positon</term>
<term>Système nerveux pathologie</term>
<term>Tomographie émission positon</term>
<term>Tomoscintigraphie</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) is a neurodegenerative disease presenting with voluntary gaze difficulties, early falls, and Parkinsonism. Neuronal loss, associated with intracellular neurofibrillary tangles and activated microglia, is found targeting the basal ganglia, brainstem nuclei, and frontal cortex. [11C](R)‐PK11195 PET is a marker of peripheral benzodiazepine binding sites (PBBS) expressed by activated microglia. We have used [11C](R)‐PK11195 PET to demonstrate in vivo the degree and distribution of the glial response to the degenerative process in four patients with PSP. Compared to normal age‐matched controls, the PSP patient group showed significantly increased mean [11C](R)‐PK11195 binding in the basal ganglia, midbrain, the frontal lobe, and the cerebellum. Two of the patients were rescanned after 6 to 10 months and during that time the level of microglial activation remained stable. [11C](R)‐PK11195 PET reveals a pattern of increased microglial activation in PSP patients involving cortical and subcortical regions that corresponds well with the known distribution of neuropathological changes. [11C](R)‐PK11195 PET, therefore, may help in characterizing in vivo the underlying disease activity in PSP. © 2005 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gerhard, Alexander" sort="Gerhard, Alexander" uniqKey="Gerhard A" first="Alexander" last="Gerhard">Alexander Gerhard</name>
</region>
<name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
<name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
<name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
<name sortKey="Trender Erhard, Iris" sort="Trender Erhard, Iris" uniqKey="Trender Erhard I" first="Iris" last="Trender-Gerhard">Iris Trender-Gerhard</name>
<name sortKey="Trender Erhard, Iris" sort="Trender Erhard, Iris" uniqKey="Trender Erhard I" first="Iris" last="Trender-Gerhard">Iris Trender-Gerhard</name>
<name sortKey="Turkheimer, Federico" sort="Turkheimer, Federico" uniqKey="Turkheimer F" first="Federico" last="Turkheimer">Federico Turkheimer</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003383 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003383 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:E14D0B5AA49F9AF524160B710910B34A5E119563
   |texte=   In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in progressive supranuclear palsy
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in progressive supranuclear palsy

In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in progressive supranuclear palsy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.